![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-t1.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0753332221006375-ga1.jpg)
Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect
![Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans | Drug Metabolism & Disposition Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans | Drug Metabolism & Disposition](https://dmd.aspetjournals.org/content/dmd/29/10/1316/F4.large.jpg)
Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans | Drug Metabolism & Disposition
![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-ga1.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/7-Figure4-1.png)
Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
nsatmi on Twitter: "well-stirredモデルによる分類整理 肝血流律速にしても、肝代謝能律速にしても、AUCに影響を与える因子は、やっぱり ・非結合形分率 ・肝固有クリアランス 肝血流の変動は、吸収↓と消失↓で相殺されるため、AUCに関与しません。 https://t.co ...
In vitro–in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: princip
![A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs? - ScienceDirect A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098722000197-ga1.jpg)
A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs? - ScienceDirect
![PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data](https://i1.rgstatic.net/publication/326965255_Discussions_on_the_hepatic_well-stirred_model_Re-derivation_from_the_dispersion_model_and_re-analysis_of_the_lidocaine_data/links/5bc64672299bf17a1c55d0cc/largepreview.png)
PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data
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Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect
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PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/2-Figure1-1.png)
Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
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Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
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Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295219302801-ga1.jpg)